We are experiencing a revolution in cancer. Advances in screening, targeted and immune therapies, big data, computational methodologies, and significant new knowledge of cancer biology are transforming the ways in which we prevent, detect, diagnose, treat, and survive cancer. These advances are enabling durable progress in the goal to achieve personalized cancer care. Despite these gains, more work is needed to develop better tools and strategies to limit cancer as a major health concern. One persistent gap is the inconsistent coordination among researchers and caregivers to implement evidence-based programs that rely on a fuller understanding of the molecular, cellular, and systems biology mechanisms underpinning different types of cancer. Here, the authors integrate conversations with over 90 leading cancer experts to highlight current challenges, encourage a robust and diverse national research portfolio, and capture timely opportunities to advance evidence-based approaches for all patients with cancer and for all communities.

中文翻译：

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癌症研究蓝图：关键差距和机遇

我们正在经历一场癌症革命。筛查、靶向和免疫疗法、大数据、计算方法和癌症生物学的重要新知识的进步正在改变我们预防、检测、诊断、治疗和存活癌症的方式。这些进步使实现个性化癌症护理的目标取得持久进展。尽管取得了这些成果，但仍需要开展更多工作来开发更好的工具和策略来限制癌症作为主要健康问题。一个持续存在的差距是研究人员和护理人员在实施循证计划时不一致的协调，这些计划依赖于对支持不同类型癌症的分子、细胞和系统生物学机制的更全面了解。这里，