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Anticancer Activities of Plant Secondary Metabolites: Rice Callus Suspension Culture as a New Paradigm
Rice Science ( IF 5.6 ) Pub Date : 2020-12-16 , DOI: 10.1016/j.rsci.2020.11.004
Wusirika Ramakrishna , Anuradha Kumari , Nafeesa Rahman , Pallavi Mandave

Plant natural products including alkaloids, polyphenols, terpenoids and flavonoids have been reported to exert anticancer activity by targeting various metabolic pathways. The biological pathways regulated by plant products can serve as novel drug targets. Plant natural compounds or their derivatives used for cancer treatment and some novel plant-based compounds which are used in clinical trials were discussed. Callus suspension culture with secondary metabolites can provide a continuous source of plant pharmaceuticals without time and space limitations. Previous research has shown that rice callus suspension culture can kill >95% cancer cells with no significant effect on the growth of normal cells. The role of candidate genes and metabolites which are likely to be involved in the process and their potential to serve as anticancer and anti-inflammatory agents were discussed. Large scale production of plant callus suspension culture and its constituents can be achieved using elicitors which enhance specific secondary metabolites combined with bioprocess technology.



中文翻译:

植物次生代谢产物的抗癌活性:水稻愈伤组织悬浮培养为新范式

据报道,包括生物碱,多酚,萜类和黄酮类在内的植物天然产物可通过靶向各种代谢途径发挥抗癌活性。植物产物调节的生物途径可以作为新型药物靶标。讨论了用于癌症治疗的植物天然化合物或其衍生物,以及一些用于临床试验的新型植物基化合物。带有次级代谢产物的愈伤组织悬浮培养可以提供连续的植物药物来源,而没有时间和空间的限制。以前的研究表明,水稻愈伤组织悬浮培养可以杀死95%以上的癌细胞,而对正常细胞的生长没有明显影响。讨论了可能与该过程有关的候选基因和代谢物的作用及其作为抗癌和抗炎药的潜力。可以使用增强特定次生代谢物的激发子结合生物加工技术来实现植物愈伤组织悬浮培养物及其成分的大规模生产。

更新日期:2020-12-16
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