Photocrosslinkable surgical adhesives provide many advantages when compared with traditional methods used in wound closure. This work aimed to develop UV-curable biodegradable adhesives based on lactic acid and PCL oligomers. Both materials were functionalized with 2-isocyanatoethyl acrylate (AOI). Subsequently, the photoinitiator (Irgacure® 2959) was added to the blend and then, the final materials were irradiated under UV light for two different times: 30 s and 2 min. After production of adhesives, its physicochemical properties were evaluated through FTIR-ATR and TGA, as well as its rheology, dynamic water contact angle, swelling capacity and hydrolytic degradation. Furthermore, the biocompatibility of the produced adhesives was also characterized in contact with human dermal fibroblasts cells. The antimicrobial activity of the materials was assessed by using Staphylococcus aureus and Escherichia coli, as bacterial models.

与用于伤口闭合的传统方法相比，可光交联的手术粘合剂具有许多优势。这项工作旨在开发基于乳酸和PCL低聚物的可紫外线固化的可生物降解胶粘剂。两种材料都用丙烯酸2-异氰酸根合乙酯（AOI）功能化。随后，将光引发剂（Irgacure®2959）添加到共混物中，然后，将最终材料在UV光下照射两个不同的时间：30 s和2 min。胶粘剂生产后，通过FTIR-ATR和TGA评估其理化性质，以及其流变性，动态水接触角，溶胀能力和水解降解性。此外，所产生的粘合剂的生物相容性还通过与人皮肤成纤维细胞接触来表征。金黄色葡萄球菌和大肠杆菌作为细菌模型。