Gastric cancer ranks as one of the most common and poor prognosis human malignancies. We investigated the radioenhancer effects of gold, silver, platinum, bismuth, iron oxide, titanium oxide and germanium nanoparticles on simulated gastric adenocarcinoma cells, irradiated with 6 MV X-rays in presence of 0.05 µM, 0.25 µM and 0.5 µM homogeneous distributed metal nanoparticles throughout the cell, including the nucleus, cytoplasm and extracellular matrix using Geant4 Monte Carlo simulation along with LEM radiobiological model. The survival reduction coefficient was obtained 0.5 for light nanoparticles including 0.5 μM titanium oxide, iron oxide and germanium and also 0.3–0.1 for heavy nanoparticles including 0.5 μM gold, silver, bismuth and platinum. Nanoparticle-mediated Enhancement Ratio for 0.5 μM internuclear Gold, Silver, Bismuth, Germanium, Platinum, Iron oxide and Titanium oxide nanoparticles was calculated to 0.10, 0.27, 0.26, 0.47, 0.09, 0.50, and 0.58, respectively. Radiosensitization by NPs may enhance therapeutic efficacy of gastric adenocarcinoma.

胃癌被认为是最常见且预后不良的人类恶性肿瘤之一。我们研究了金，银，铂，铋，氧化铁，氧化钛和锗的纳米粒子对模拟胃腺癌细胞的放射增强作用，在0.05 µM，0.25 µM和0.5 µM均匀分布的金属纳米粒子存在下，用6 MV X射线辐照使用Geant4 Monte Carlo模拟以及LEM放射生物学模型对整个细胞进行整个分析，包括细胞核，细胞质和细胞外基质。对于包含0.5μM氧化钛，氧化铁和锗的轻纳米粒子，生存减少系数为0.5；对于包含0.5μM金，银，铋和铂的重纳米粒子，生存减少系数为0.3-0.1。纳米粒子介导的0.5μM核金，银，铋，锗，计算出铂，氧化铁和氧化钛纳米粒子分别为0.10、0.27、0.26、0.47、0.09、0.50和0.58。NPs的放射增敏作用可以增强胃腺癌的治疗效果。