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What NIR photodynamic activation offers molecular targeted nanomedicines: Perspectives into the conundrum of tumor specificity and selectivity
Nano Today ( IF 13.2 ) Pub Date : 2020-12-16 , DOI: 10.1016/j.nantod.2020.101052 Chanda Bhandari 1 , Mina Guirguis 1 , N Anna Savan 2 , Navadeep Shrivastava 1 , Sabrina Oliveira 3, 4 , Tayyaba Hasan 5, 6 , Girgis Obaid 1
Nano Today ( IF 13.2 ) Pub Date : 2020-12-16 , DOI: 10.1016/j.nantod.2020.101052 Chanda Bhandari 1 , Mina Guirguis 1 , N Anna Savan 2 , Navadeep Shrivastava 1 , Sabrina Oliveira 3, 4 , Tayyaba Hasan 5, 6 , Girgis Obaid 1
Affiliation
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Near infrared (NIR) photodynamic activation is playing increasingly critical roles in cutting-edge anti-cancer nanomedicines, which include spatiotemporal control over induction of therapy, photodynamic priming, and phototriggered immunotherapy. Molecular targeted photonanomedicines (mt-PNMs) are tumor-specific nanoscale drug delivery systems, which capitalize on the unparalleled spatio-temporal precision of NIR photodynamic activation to augment the accuracy of tumor tissue treatment. mt-PNMs are emerging as a paradigm approach for the targeted treatment of solid tumors, yet remain highly complex and multifaceted. While ligand targeted nanomedicines in general suffer from interdependent challenges in biophysics, surface chemistry and nanotechnology, mt-PNMs provide distinct opportunities to synergistically potentiate the effects of ligand targeting. This review provides what we believe to be a much-need demarcation between the processes involved in (biomolecular recognition events) and (preferential tumor accumulation) of ligand targeted nanomedicines, such as mt-PNMs, and elaborate on what NIR photodynamic activation has to offer. We discuss the interplay between both tumor specificity and tumor selectivity and the degree to which both may play central roles in cutting-edge NIR photoactivable nanotechnologies. A special emphasis is made on NIR photoactivable biomimetic nanotechnologies that capitalize on both specificity and selectivity phenomena to augment the safety and efficacy of photodynamic anti-tumor regimens.
中文翻译：
近红外光动力激活为分子靶向纳米药物提供了什么：肿瘤特异性和选择性难题的视角
近红外（NIR）光动力激活在尖端抗癌纳米药物中发挥着越来越重要的作用，其中包括治疗诱导的时空控制、光动力启动和光触发免疫治疗。分子靶向光纳米药物（mt-PNM）是肿瘤特异性纳米级药物输送系统，它利用近红外光动力激活无与伦比的时空精度来提高肿瘤组织治疗的准确性。 mt-PNM 正在成为实体瘤靶向治疗的范例方法，但仍然高度复杂和多方面。虽然配体靶向纳米药物通常面临生物物理学、表面化学和纳米技术方面相互依赖的挑战，但 mt-PNM 提供了独特的机会来协同增强配体靶向的效果。这篇综述提供了我们认为配体靶向纳米药物（例如 mt-PNM）所涉及的（生物分子识别事件）和（优先肿瘤积累）过程之间急需的界限，并详细说明了近红外光动力激活所提供的功能。我们讨论了肿瘤特异性和肿瘤选择性之间的相互作用，以及两者在尖端近红外光激活纳米技术中发挥核心作用的程度。特别强调近红外光活化仿生纳米技术，该技术利用特异性和选择性现象来增强光动力抗肿瘤方案的安全性和有效性。
更新日期：2020-12-16
中文翻译：
近红外光动力激活为分子靶向纳米药物提供了什么：肿瘤特异性和选择性难题的视角
近红外（NIR）光动力激活在尖端抗癌纳米药物中发挥着越来越重要的作用，其中包括治疗诱导的时空控制、光动力启动和光触发免疫治疗。分子靶向光纳米药物（mt-PNM）是肿瘤特异性纳米级药物输送系统，它利用近红外光动力激活无与伦比的时空精度来提高肿瘤组织治疗的准确性。 mt-PNM 正在成为实体瘤靶向治疗的范例方法，但仍然高度复杂和多方面。虽然配体靶向纳米药物通常面临生物物理学、表面化学和纳米技术方面相互依赖的挑战，但 mt-PNM 提供了独特的机会来协同增强配体靶向的效果。这篇综述提供了我们认为配体靶向纳米药物（例如 mt-PNM）所涉及的（生物分子识别事件）和（优先肿瘤积累）过程之间急需的界限，并详细说明了近红外光动力激活所提供的功能。我们讨论了肿瘤特异性和肿瘤选择性之间的相互作用，以及两者在尖端近红外光激活纳米技术中发挥核心作用的程度。特别强调近红外光活化仿生纳米技术，该技术利用特异性和选择性现象来增强光动力抗肿瘤方案的安全性和有效性。
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