Decline in biological resilience (ability to recover) is a key manifestation of aging that contributes to increase in vulnerability to death with age eventually limiting longevity even in people without major chronic diseases. Understanding the mechanisms of this decline is essential for developing efficient anti-aging and pro-longevity interventions. In this paper we discuss: a) mechanisms of the decline in resilience with age, and aging components that contribute to this decline, including depletion of body reserves, imperfect repair mechanisms, and slowdown of physiological processes and responses with age; b) anti-aging interventions that may improve resilience or attenuate its decline; c) biomarkers of resilience available in human and experimental studies; and d) genetic factors that could influence resilience. There are open questions about optimal anti-aging interventions that would oppose the decline in resilience along with extending longevity limits. However, the area develops quickly, and prospects are exciting.

生物复原力（恢复能力）的下降是衰老的一个关键表现，随着年龄的增长，死亡的脆弱性增加，最终会限制寿命，即使没有重大慢性病的人也是如此。了解这种下降的机制对于开发有效的抗衰老和延长寿命的干预措施至关重要。在本文中，我们讨论： a) 弹性随年龄下降的机制，以及导致这种下降的衰老因素，包括身体储备的消耗、不完善的修复机制以及生理过程和反应随年龄增长的减慢；b) 可以提高复原力或减缓其衰退的抗衰老干预措施；c) 人类和实验研究中可用的复原力生物标志物；d) 可能影响恢复力的遗传因素。关于最佳抗衰老干预措施存在一些悬而未决的问题，这些干预措施将反对弹性下降以及延长寿命限制。然而，该地区发展迅速，前景令人兴奋。