Accumulating studies revealed the vital role of ion channels in cancers, but the prognosis role of ion channels in hepatocellular carcinoma (HCC) remains limited. Here, we developed and validated an ion channel signature for prognostic prediction of HCC patients. In total, 35 differential expressed ion channel genes (DEChannelGs) were identified in HCC and a novel ion channel risk model was established for HCC prognosis prediction using the TCGA cohort, which was validated using the ICGC cohort. Moreover, this risk model was an independent prognostic factor and was associated with the immune microenvironment in HCC. Finally, the mRNA and protein levels of ANO10 and CLCN2 were prominently up-regulated and were related to the poor prognosis of HCC patients. Taken together, these results indicated a novel ion channel risk model as a prognostic biomarker for HCC patients and provided further insight into its immunoregulatory mechanism in HCC progression.

越来越多的研究揭示了离子通道在癌症中的重要作用，但离子通道在肝细胞癌（HCC）中的预后作用仍然有限。在这里，我们开发并验证了用于 HCC 患者预后预测的离子通道特征。总共在 HCC 中鉴定了 35 个差异表达离子通道基因 (DEChannelGs)，并使用 TCGA 队列建立了一种新的离子通道风险模型用于 HCC 预后预测，并使用 ICGC 队列进行了验证。此外，这种风险模型是一个独立的预后因素，并且与 HCC 的免疫微环境相关。最后，ANO10 和 CLCN2 的 mRNA 和蛋白水平显着上调，与 HCC 患者的不良预后有关。综合起来，