Background

The purpose of this review was to evaluate the consistency of central corneal thickness (CCT) values reported with use of Topcon SP-2000 P and SP-3000 P non-contact specular microscopes since their introduction in 1999 with the two microscopes having been commonly used in a wide range of studies.

Methods

As a primary resource, PubMed was used to search for peer-reviewed articles in any language that included CCT values obtained with non-contact specular microscopy reported for humans with nominally healthy corneas. Relevant articles were obtained and any cited publications also checked.

Results

A total of 76 articles were identified which reported CCT on different small-to-moderate sized groups of individuals, published between 1999 and 2019. From these, an overall group mean CCT value of 0.525 ± 0.013 mm (median 0.525 mm) can be calculated. An estimated 95 % confidence interval (CI, based on 1.96 SD) would be between 0.500 and 0.550 mm. For the two Topcon models, the group mean ± SD values were 0.529 ± 0.013 mm and 0.517 ± 010 mm respectively. An assessment of the CCT data sets in relation to the reported average age indicated no statistically significant effect (p = 0.289, r = −0.129). Very similar average CCT values were also encountered in 4 other reports where these microscopes were used in large-scale population studies as well as in 2 other reports using the newer Topcon SP-1 P model.

Conclusions

The Topcon stand-alone non-contact specular microscopes have yielded consistent and predictable corneal thickness measures over many years.

中文翻译：

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使用 Topcon 仪器评估健康人眼中央角膜厚度的非接触式镜面显微镜——20 年回顾

背景

本综述的目的是评估自 1999 年推出以来使用 Topcon SP-2000 P 和 SP-3000 P 非接触镜面显微镜报告的中央角膜厚度 (CCT) 值的一致性，这两种显微镜已被普遍使用在广泛的研究中。

方法

作为主要资源，PubMed 被用于搜索任何语言的同行评审文章，其中包括使用非接触镜面显微镜获得的 CCT 值，报告为具有名义健康角膜的人类报告。获得了相关文章并检查了任何引用的出版物。

结果

总共确定了 76 篇文章，它们报告了 1999 年至 2019 年间发表的不同中小型个体组的 CCT。从这些文章中，可以计算出整个组的平均 CCT 值为 0.525 ± 0.013 毫米（中值 0.525 毫米） . 估计的 95% 置信区间（CI，基于 1.96 SD）将介于 0.500 和 0.550 毫米之间。对于两个 Topcon 模型，组均值 ± SD 值分别为 0.529 ± 0.013 mm 和 0.517 ± 010 mm。与报告的平均年龄相关的 CCT 数据集的评估表明没有统计学上的显着影响（p = 0.289，r = -0.129）。在其他 4 份报告中也遇到了非常相似的平均 CCT 值，其中这些显微镜用于大规模人口研究，以及其他 2 份使用较新的 Topcon SP-1 P 模型的报告。

结论

多年来，Topcon 独立式非接触镜面显微镜已经产生了一致且可预测的角膜厚度测量值。