Abstract—

Inflammation plays a substantial role in the pathophysiology of schizophrenia. The neutrophil to lymphocyte ratio (NLR) is a cost-effective and simple indicator of inflammation, which it is widely used as a proxy of systemic inflammation. In this retrospective study, we investigated the relationship between NLR and early-onset schizophrenia. Hematologic parameters and Positive and Negative Syndrome Scale (PANSS) scores were obtained from the medical records of 32 patients. NLR values and hematologic parameters were compared with 32 age- and sex-matched healthy controls. The mean NLR was significantly higher in patients than in controls. The neutrophil count was significantly higher in the patient group; however, leukocyte, haemoglobin, lymphocyte, and platelet counts did not differ between groups. No significant correlation was found between PANSS scores and NLR in the patient group. Our findings suggest that elevated NLR is an inflammation biomarker that plays a role in the pathophysiology of schizophrenia.

中文翻译：

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早发性精神分裂症青少年中性粒细胞/淋巴细胞比率升高

摘要-

炎症在精神分裂症的病理生理中起重要作用。中性粒细胞与淋巴细胞的比率（NLR）是炎症的一种经济有效的简单指标，它被广泛用作全身性炎症的代表。在这项回顾性研究中，我们调查了NLR与早发性精神分裂症之间的关系。血液学参数和正负综合症量表（PANSS）得分来自32例患者的病历。将NLR值和血液学参数与32位年龄和性别相匹配的健康对照进行比较。患者的平均NLR明显高于对照组。患者组中性粒细胞计数明显更高；但是，两组之间的白细胞，血红蛋白，淋巴细胞和血小板计数没有差异。在患者组中，PANSS评分与NLR之间未发现显着相关性。我们的发现表明，NLR升高是一种炎症生物标志物，在精神分裂症的病理生理中起作用。