Abstract—Post-stroke depression (PD) is a complex multifactorial disease that affects over 30% of stroke survivors. Despite the high prevalence of the disease, important aspects of its classification, etiology, and pathogenesis are still not fully understood, which is complicated even further by significant difficulties in diagnostics and prevention. Subjective depression rating scales and physical examination as primary methods for diagnosis of post-stroke depression strongly depend on the doctor. The use of specific biomarkers may be effective, however, their identification, validation, and introduction to everyday practice continues to be a challenge. It is still not known whether potential biomarkers for post-stroke depression are a combination of depression and stroke markers, or whether they bear a certain specificity. The current review analyzes data on biomarkers shared by stroke, depression, and post-stroke depression. A number of PD biomarkers overlap with stroke and depression markers, however, some differences are also present (IFN-γ, serum ferritin, VEGF, serotonin, dopamine, and miRNA expression). On the other hand, stroke has an impact on the expression of depression markers. To identify biomarkers specific for post-stroke depression, further extensive studies are necessary.

摘要-中风后抑郁症（PD）是一种复杂的多因素疾病，会影响超过30％的中风幸存者。尽管该疾病的流行率很高，但其分类，病因和发病机理的重要方面仍未完全了解，由于诊断和预防方面的重大困难，这一问题更加复杂。主观抑郁评分量表和体格检查是诊断卒中后抑郁的主要方法，在很大程度上取决于医生。特定生物标志物的使用可能是有效的，但是，它们的识别，验证和日常操作介绍仍然是一个挑战。尚不清楚中风后抑郁的潜在生物标记物是否是抑郁症和中风标记物的组合，或者它们是否具有一定的特异性。本综述分析了卒中，抑郁和中风后抑郁共享的生物标志物数据。许多PD生物标志物与中风和抑郁标志物重叠，但是，也存在一些差异（IFN-γ，血清铁蛋白，VEGF，5-羟色胺，多巴胺和miRNA表达）。另一方面，中风对抑郁标志物的表达有影响。为了鉴定中风后抑郁的特异性生物标志物，需要进一步的广泛研究。