The antidepressant venlafaxine is largely O-desmethylated by CYP2D6, whereas CYP2C19 mediates an alternative metabolic route of venlafaxine through N-desmethylation. The aim of this study was to investigate the combined effect of genotype-predicted CYP2D6 and CYP2C19 phenotypes on serum concentrations of venlafaxine and metabolites in a large patient population.

中文翻译：

---

CYP2D6和CYP2C19组合基因型对一个大型患者队列中的文拉法辛和O-去甲基文拉法辛浓度的影响。

抗抑郁药文拉法辛主要通过CYP2D6 O-去甲基化，而CYP2C19通过N-去甲基化介导文拉法辛的另一种代谢途径。本研究的目的是研究基因型预测的CYP2D6和CYP2C19表型对大量患者的venlafaxine和代谢产物血清浓度的联合作用。