Advances in single-cell biotechnology have increasingly revealed interactions of cells with their surroundings, suggesting a cellular society at the microscale. Similarities between cells and humans across multiple hierarchical levels have quantitative inference potential for reaching insights about phenotypic interactions that lead to morphological forms across multiple scales of cellular organization, namely cells, tissues and organs. Here, the functional and structural comparisons between how cells and individuals fundamentally socialize to give rise to the spatial organization are investigated. Integrative experimental cell interaction assays and computational predictive methods shape the understanding of societal perspective in the determination of the cellular interactions that create spatially coordinated forms in biological systems. Emerging quantifiable models from a simpler biological microworld such as bacterial interactions and single-cell organisms are explored, providing a route to model spatio-temporal patterning of morphological structures in humans. This analogical reasoning framework sheds light on structural patterning principles as a result of biological interactions across the cellular scale and up.

单细胞生物技术的进步越来越多地揭示了细胞与其周围环境的相互作用，这表明了微观尺度上的细胞社会。跨多个层次级别的细胞和人类之间的相似性具有定量推理潜力，可以深入了解导致跨多个细胞组织尺度（即细胞、组织和器官）的形态学形式的表型相互作用。在这里，研究了细胞和个体如何从根本上社会化以产生空间组织之间的功能和结构比较。综合实验细胞相互作用分析和计算预测方法塑造了对确定在生物系统中创建空间协调形式的细胞相互作用的社会观点的理解。探索了来自更简单的生物微观世界的新兴可量化模型，例如细菌相互作用和单细胞生物，为模拟人类形态结构的时空模式提供了途径。这种类比推理框架阐明了结构模式原理，这是跨细胞规模及以上生物相互作用的结果。