The ketogenic diet (KD) can promote the anti-inflammatory metabolic state and increase ketone body level in rats. This study was to explore the effects and differences of KD with or without medium-chain fatty acids (MCFAs) on serum inflammatory factors and mTOR pathway in Sprague–Dawley (SD) rats. Male SD rats were assigned to five groups: control diet (C), 20% caloric restriction diet (LC), 20% caloric restriction ketogenic diet (containing MCFAs) (LCKD1), 20% caloric restriction ketogenic diet (LCKD2) and 20% caloric restriction foreign ketogenic diet (LCKD3), and fed for 30 d. LC and KD could significantly reduce the body weight of rats; LC and KD containing MCFAs showed anti-inflammatory effects; KD without MCFAs decreased the concentration of mTOR1, while KD containing MCFAs decreased the expression of AMPK, mtor1 and P70sk. KD containing MCFAs showed better effects on the mTOR pathway and anti-inflammation than that without MCFAs.

中文翻译：

---

生酮饮食含中链脂肪酸对大鼠血清炎症因子和mTOR信号通路的影响

生酮饮食（KD）可以促进大鼠的抗炎代谢状态并增加酮体水平。这项研究旨在探讨含或不含中链脂肪酸（MCFA）的KD对Sprague-Dawley（SD）大鼠血清炎性因子和mTOR途径的影响和差异。将雄性SD大鼠分为五组：对照饮食（C），20％热量限制生酮饮食（LCKD1），20％热量限制生酮饮食（LCKD1），20％热量限制生酮饮食（LCKD2）和20％限制热量外生酮饮食（LCKD3），并喂食30 d。LC和KD可以显着降低大鼠的体重；含有LC和KD的MCFA显示出抗炎作用；没有MCFA的KD降低了mTOR1的浓度，而含有MCFA的KD降低了AMPK，mtor1和P70sk的表达。