Biocompatible polymer-coated magnetic nanoparticles are designed with an objective to sharp-shoot cancer by loading anticancer drugs on them and delivering to the target site. In this work, novel biocompatible polymers of poly(dl-lactic-co-glycolide), functionalized with β-cyclodextrin and β-cyclodextrin-folate conjugate are synthesized and characterized by spectroscopic techniques. Magnetic ytterbium ferrite nanoparticles are prepared, and the synthesized polymers are coated on them. The polymer-coated nanoparticles are intended to be employed as magnetic nanocarriers that transport the anticancer drug, camptothecin. The ferrite nanoparticles are superparamagnetic in nature. Camptothecin was loaded in the nanocarriers and the adsorption percentage was near or above 90%. Study of the in vitro release of camptothecin from the nanocarrier reveals its sustained nature, i.e. a cumulative release of about 50% at 72 h and a pH of 7.4. A pH-dependent enhanced release of 60% is observed, i.e. at a more acidic pH of 6.8. In vitro anti-cancer studies on breast cancer cell lines (MCF7) were carried out. The cell inhibition is enhanced in the case of camptothecin-loaded nanocarrier. The enhanced efficacy of the camptothecin, its sustained release, and the size of the nanocarrier in the range that is considered suitable for magnetic field-assisted drug delivery reveal the magnetic nanocarrier promising for transport of the drug.

设计具有生物相容性的聚合物包覆的磁性纳米颗粒，其目的是通过在抗癌药物上装载抗癌药物并将其递送至目标部位来锐化癌症。在这项工作中，聚（dl-lactic- coβ-环糊精和β-环糊精-叶酸酯共轭物官能化的乙交酯）通过光谱技术进行合成和表征。制备了磁性fer铁氧体纳米粒子，并将合成的聚合物涂覆在其上。涂覆有聚合物的纳米颗粒旨在用作转运抗癌药物喜树碱的磁性纳米载体。铁氧体纳米粒子本质上是超顺磁性的。喜树碱负载在纳米载体中，吸附百分比接近或高于90％。喜树碱从纳米载体中的体外释放研究表明其具有持续性，即在72 h的pH值为7.4时累积释放约50％。观察到60％的pH依赖性增强释放，即在更酸性的6.8处。对乳腺癌细胞系（MCF7）进行了体外抗癌研究。在载有喜树碱的纳米载体的情况下，细胞抑制作用增强。喜树碱的增强功效，其持续释放以及纳米载体的大小在被认为适合于磁场辅助药物递送的范围内，揭示了磁性纳米载体有望用于药物的运输。