Introduction

COVID-19 is a multi-system infection which predominantly affects the respiratory system, but also causes systemic inflammation, endothelialitis and thrombosis. The consequences of this include renal dysfunction, hepatitis and stroke. In this systematic review, we aimed to evaluate the epidemiology, clinical course, and outcomes of patients who suffer from stroke as a complication of COVID-19.

Methods

We conducted a systematic review of all studies published between November 1, 2019 and July 8, 2020 which reported on patients who suffered from stroke as a complication of COVID-19.

Results

326 studies were screened, and 30 studies reporting findings from 55,176 patients including 899 with stroke were included. The average age of patients who suffered from stroke as a complication of COVID-19 was 65.5 (Range: 40.4–76.4 years). The average incidence of stroke as a complication of COVID-19 was 1.74% (95% CI: 1.09% to 2.51%). The average mortality of stroke in COVID-19 patients was 31.76% (95% CI: 17.77% to 47.31%). These patients also had deranged clinical parameters including deranged coagulation profiles, liver function tests, and full blood counts.

Conclusion

Although stroke is an uncommon complication of COVID-19, when present, it often results in significant morbidity and mortality. In COVID-19 patients, stroke was associated with older age, comorbidities, and severe illness.

中文翻译：

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中风作为 COVID-19 的神经系统并发症：对发病率、结果和预测因子的系统评价和荟萃分析

介绍

COVID-19是一种多系统感染，主要影响呼吸系统，但也会引起全身炎症、内皮炎和血栓形成。其后果包括肾功能障碍、肝炎和中风。在本系统评价中，我们旨在评估 COVID-19 并发症中风患者的流行病学、临床病程和结局。

方法

我们对 2019 年 11 月 1 日至 2020 年 7 月 8 日期间发表的所有研究进行了系统回顾，这些研究报告了因 COVID-19 并发症而患中风的患者。

结果

筛选了 326 项研究，其中 30 项研究报告了来自 55,176 名患者的发现，其中包括 899 名中风患者。作为 COVID-19 并发症的中风患者的平均年龄为 65.5 岁（范围：40.4-76.4 岁）。中风作为 COVID-19 并发症的平均发生率为 1.74%（95% CI：1.09% 至 2.51%）。COVID-19 患者中风的平均死亡率为 31.76%（95% CI：17.77% 至 47.31%）。这些患者还具有异常的临床参数，包括异常的凝血曲线、肝功能测试和全血细胞计数。

结论

尽管中风是 COVID-19 的一种罕见并发症，但一旦出现，通常会导致显着的发病率和死亡率。在 COVID-19 患者中，中风与年龄较大、合并症和严重疾病有关。