Deep brain stimulation (DBS) is used to treat a wide array of neurologic conditions. However, traditional programming of stimulation parameters relies upon short term subjective observation of patient symptoms and undesired stimulation effects while in the clinic. To gain a more objective measure of the neuronal activity that contributes to patient symptoms and response to treatment, there is a clear need for a fully-implantable DBS system capable of chronically recording patient-specific electrophysiological biomarker signals over time. By providing an objective correlate of a patient's disease and response to treatment, this capability has the potential to improve therapeutic benefit while preventing undesirable side effects. Herein, the engineering and capabilities of the Percept PC, the first FDA-approved, fully-implantable DBS device capable of nearly-simultaneous electrophysiological recordings and stimulation, are discussed. The device's ability to chronically record local field potentials (LFPs) at implanted DBS leads was validated in patients with neurological disorders. Lastly, the electrophysiological activity correlates of clinically relevant patient-reported events are presented. While FDA approved for conditions such as Parkinson's disease, essential tremor, dystonia, obsessive-compulsive disorder, and epilepsy, chronic electrophysiological recordings in humans has broad applications within basic science and clinical practice beyond DBS, offering a wealth of information related to normal and abnormal neurophysiology within distinct brain areas.

深部脑刺激（DBS）用于治疗多种神经系统疾病。然而，刺激参数的传统编程依赖于在临床中对患者症状和不期望的刺激效果的短期主观观察。为了更客观地测量导致患者症状和治疗反应的神经元活动，显然需要一种完全植入式 DBS 系统，能够随着时间的推移长期记录患者特定的电生理生物标志物信号。通过提供患者疾病和治疗反应的客观关联，这种能力有可能提高治疗效果，同时防止不良副作用。本文讨论了 Percept PC 的工程设计和功能，Percept PC 是首款经 FDA 批准的完全植入式 DBS 设备，能够几乎同时进行电生理记录和刺激。该设备长期记录植入 DBS 导线局部场电位 (LFP) 的能力已在神经系统疾病患者中得到验证。最后，提出了临床相关患者报告事件的电生理活动相关性。虽然 FDA 批准用于帕金森病、特发性震颤、肌张力障碍、强迫症和癫痫等疾病，但人体慢性电生理记录在 DBS 之外的基础科学和临床实践中具有广泛的应用，提供与正常和异常相关的大量信息不同大脑区域的神经生理学。