Identification of a differentiation stall in epithelial mesenchymal transition in histone H3–mutant diffuse midline glioma,GigaScience

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Identification of a differentiation stall in epithelial mesenchymal transition in histone H3–mutant diffuse midline glioma
GigaScience ( IF 11.8 ) Pub Date : 2020-12-15 , DOI: 10.1093/gigascience/giaa136
Lauren M Sanders _{1,

2} , Allison Cheney ₃ , Lucas Seninge _{1,

2} , Anouk van den Bout _{2,

3} , Marissa Chen _{2,

3} , Holly C Beale _{2,

3} , Ellen Towle Kephart ₂ , Jacob Pfeil _{1,

2} , Katrina Learned ₂ , A Geoffrey Lyle _{2,

3} , Isabel Bjork ₂ , David Haussler _{1,

2,

4} , Sofie R Salama _{1,

2,

4} , Olena M Vaske _{2,

3}

Affiliation

Diffuse midline gliomas with histone H3 K27M (H3K27M) mutations occur in early childhood and are marked by an invasive phenotype and global decrease in H3K27me3, an epigenetic mark that regulates differentiation and development. H3K27M mutation timing and effect on early embryonic brain development are not fully characterized.

中文翻译：

组蛋白 H3 突变型弥漫性中线神经胶质瘤上皮间质转化分化停滞的鉴定

具有组蛋白 H3 K27M (H3K27M) 突变的弥漫性中线神经胶质瘤发生在儿童早期，其特点是侵袭性表型和 H3K27me3（一种调节分化和发育的表观遗传标记）的整体减少。 H3K27M 突变时间和对早期胚胎大脑发育的影响尚未完全确定。

更新日期：2020-12-15

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