ABSTRACT

Background: To investigate the effects of insulin glargine injection given with a QS-P jet injector on the glucose profile using a professional mode flash glucose monitoring (FGM) system in patients with type 2 diabetes mellitus (T2DM).

Research design and methods: In this randomized, controlled, cross-sectional study, 66 patients with T2DM who received insulin glargine (12–18 IU/day) injection were enrolled. The patients were randomly divided into group A (jet injector before insulin pen) and group B (insulin pen before jet injector). Each subject injected insulin daily before breakfast. We analyzed the changes in the glucose profile using a professional mode FGM system.

Results: Treatment with a jet injector led to significantly lower 24-h mean glucose, maximum blood glucose, area under the curve (AUC) > 10.0 mmol/L, time above range and increased AUC < 3.9 mmol/L and time below range than those when using an insulin pen. There was no difference in glycemic variability between the two groups. We observed that patients using a jet injector had significantly lower mean glucose between 12:00 to 22:00.

Conclusions: Needle-free jet injection of insulin glargine was more effective than use of an insulin pen for good glycemic control in patients with T2DM.

Clinical trial registration: www.clinicaltrials.gov identifier is NCT04093284.

摘要

背景：使用专业模式快速血糖监测 (FGM) 系统研究使用 QS-P 喷射注射器注射甘精胰岛素对 2 型糖尿病 (T2DM) 患者血糖谱的影响。

研究设计和方法：在这项随机、对照、横断面研究中，招募了 66 名接受甘精胰岛素（12-18 IU/天）注射的 T2DM 患者。将患者随机分为A组（注射胰岛素笔前注射）和B组（注射注射胰岛素前注射胰岛素）。每个受试者每天在早餐前注射胰岛素。我们使用专业模式 FGM 系统分析了葡萄糖曲线的变化。

结果：使用喷射注射器治疗导致显着降低 24 小时平均葡萄糖、最大血糖、曲线下面积 (AUC) > 10.0 mmol/L、高于范围的时间和增加的 AUC < 3.9 mmol/L 和低于范围的时间那些使用胰岛素笔的人。两组之间的血糖变异性没有差异。我们观察到，使用喷射注射器的患者在 12:00 至 22:00 之间的平均血糖显着降低。

结论：在 T2DM 患者中，无针喷射注射甘精胰岛素比使用胰岛素笔更有效地控制血糖。

临床试验注册：www.clinicaltrials.gov 标识符为 NCT04093284。