Mycobacterium abscessus exhibits Arr (ADP-ribosyltransferase)-dependent rifampin resistance. In apparent contrast, rifabutin (RBT) has demonstrated promising activity in M. abscessus infection models, implying that RBT might not be inactivated by Arr. RBT susceptibility testing of M. abscessus Δarr revealed a strongly decreased MIC. Our findings suggest that the efficacy of RBT might be enhanced by rendering RBT resilient to Arr-dependent modification or by blocking M. abscessus Arr activity.

中文翻译：

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利福布汀被脓肿分枝杆菌 Arr 灭活

脓肿分枝杆菌表现出 Arr（ADP-核糖基转移酶）依赖性利福平耐药性。明显相反，利福布汀 (RBT) 在M. abscessus感染模型中表现出有希望的活性，这意味着 RBT 可能不会被 Arr 灭活。M. abscessus Δarr 的RBT 敏感性测试显示 MIC 显着降低。我们的研究结果表明，通过使 RBT 对依赖于 Arr 的修饰具有弹性或通过阻止M. abscessus Arr 活性，可能会增强 RBT 的功效。