Pain pathways and potential new targets for pain relief,Biotechnology and Applied Biochemistry

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Pain pathways and potential new targets for pain relief
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2020-12-14 , DOI: 10.1002/bab.2086
Menglan Wang ₁ , Baskaran Thyagarajan ₁

Affiliation

Pain is an unpleasant sensory and emotional experience that affects a sizable percentage of people on a daily basis. Sensory neurons known as nociceptors built specifically to detect damaging stimuli can be found throughout the body. They transmit information about noxious stimuli from mechanical, thermal, and chemical sources to the central nervous system and higher brain centers via electrical signals. Nociceptors express various channels and receptors such as voltage-gated sodium and calcium channels, transient receptor potential channels, and opioid receptors that allow them to respond in a highly specific manner to noxious stimuli. Attenuating the pain response can be achieved by inhibiting or altering the expression of these pain targets. Achieving a deeper understanding of how these receptors can be affected at the molecular level can lead to the development of novel pain therapies. This review will discuss the mechanisms of pain, introduce the various receptors that are responsible for detecting pain, and future directions in pharmacological therapies.

中文翻译：

疼痛途径和缓解疼痛的潜在新靶点

疼痛是一种不愉快的感官和情感体验，每天都会影响相当大比例的人。被称为伤害感受器的感觉神经元专门用于检测破坏性刺激，遍布全身。它们通过电信号将来自机械、热和化学源的有害刺激信息传递到中枢神经系统和更高的大脑中心。伤害感受器表达各种通道和受体，例如电压门控钠和钙通道、瞬时受体电位通道和阿片受体，这些通道和受体使它们能够以高度特异性的方式对有害刺激作出反应。减轻疼痛反应可以通过抑制或改变这些疼痛目标的表达来实现。深入了解这些受体如何在分子水平上受到影响可以促进新型疼痛疗法的开发。这篇综述将讨论疼痛的机制，介绍负责检测疼痛的各种受体，以及药物治疗的未来方向。

更新日期：2020-12-14

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