Objective

To compare the dose, cardiopulmonary effects and quality of anaesthetic induction in dogs using propofol (10 mg mL^–1) and diluted propofol (5 mg mL^–1).

Study design

Randomized, blinded, clinical study.

Animals

A total of 28 client-owned dogs (12 males/16 females).

Methods

Following intramuscular acepromazine (0.02 mg kg^–1) and methadone (0.2 mg kg^–1), propofol (UP, 10 mg mL^–1) or diluted propofol (DP, 5 mg mL^–1) was administered intravenously (0.2 mL kg^–1 minute^–1) by an anaesthetist unaware of the allocated group to achieve tracheal intubation. Sedation, intubation and induction quality were scored from 0 to 3. Pre- and post-induction pulse rate (PR), respiratory rate (f_R) and systolic (SAP), mean (MAP) and diastolic (DAP) arterial blood pressure were compared. Time to first breath and induction dose were recorded. Data were analysed for normality and Mann–Whitney U or Student t tests were performed where appropriate. Significance was set at p < 0.05. Data are presented as mean ± standard deviation or median (range).

Results

The propofol dose administered to achieve induction was lower in the DP group (2.62 ± 0.48 mg kg^–1) than in the UP group (3.48 ± 1.17 mg kg^–1) (p = 0.021). No difference was observed in pre- and post-induction PR, SAP, MAP, DAP and f_R between groups. The differences between post-induction and pre-induction values of these variables were also similar between groups. Time to first breath did not differ between groups. Sedation scores were similar between groups. Quality of tracheal intubation was marginally better with UP 0 (0–1) than with DP 1 (0–2) (p = 0.036), but overall quality of induction was similar between groups [UP 0 (0–1) and DP 0 (0–1), p = 0.549].

Conclusion and clinical relevance

Diluting propofol reduced the dose to induce anaesthesia without significantly altering the cardiopulmonary variables.

中文翻译：

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稀释和未稀释丙泊酚对犬麻醉诱导的剂量要求和心肺作用

客观的

^{比较使用丙泊酚 (10 mg mL –1} ) 和稀释的丙泊酚 (5 mg mL ^–1 )对狗进行麻醉诱导的剂量、心肺效应和质量。

学习规划

随机、盲法、临床研究。

动物

共有 28 只客户拥有的狗（12 男/16 女）。

方法

肌注乙酰丙嗪 (0.02 mg kg ^–1 ) 和美沙酮 (0.2 mg kg ^–1 ) 后，静脉注射丙泊酚 (UP, 10 mg mL ^–1 ) 或稀释的丙泊酚 (DP, 5 mg mL ^{–1 ) (0.2 mL kg – 1}分钟^–1 ) 由不知道分配组的麻醉师完成气管插管。镇静、插管和诱导质量评分从 0 到 3。诱导前和诱导后脉率 (PR)、呼吸频率 ( f _R ) 和收缩压 (SAP)、平均 (MAP) 和舒张压 (DAP) 动脉血压分别为比较的。记录第一次呼吸的时间和诱导剂量。分析数据的正态性和 Mann-Whitney U或 Studentt测试在适当的地方进行。显着性设定为p < 0.05。数据表示为平均值±标准差或中位数（范围）。

结果

^{DP 组（2.62 ± 0.48 mg kg –1} ）为实现诱导所施用的丙泊酚剂量低于UP 组（3.48 ± 1.17 mg kg ^–1）（p = 0.021）。诱导前和诱导后的 PR、SAP、MAP、DAP 和f _R组间未观察到差异。这些变量的诱导后和诱导前值之间的差异在组间也相似。第一次呼吸的时间在各组之间没有差异。组间镇静评分相似。UP 0 (0-1) 的气管插管质量略好于 DP 1 (0-2) ( p = 0.036)，但两组之间的总体诱导质量相似 [UP 0 (0-1) 和 DP 0 (0–1), p = 0.549]。

结论和临床相关性

稀释异丙酚可减少诱导麻醉的剂量，而不会显着改变心肺变量。