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Paying a Price Twice: Dose-Dependent Effects of Treg Cell-Derived TGF- β on Tolerance
Immunity ( IF 25.5 ) Pub Date : 2020-12-15 , DOI: 10.1016/j.immuni.2020.11.008
Hailey Brown , Daria Esterházy

Although many immune cells can secrete TGF-β, whether all sources of TGF-β are functionally equivalent is unknown. In this issue, Turner et al. uncover the importance of T regulatory (Treg) cell-intrinsic Tgfb1 gene dose in the prevention of autoimmunity and allergic disease.



中文翻译:

支付两次价格:Treg细胞衍生的TGF-β对耐受性的剂量依赖性作用

尽管许多免疫细胞可以分泌TGF-β,但尚不清楚TGF-β的所有来源是否功能相同。在本期中,Turner等人。揭示了T调节(Treg)细胞内在性Tgfb1基因剂量在预防自身免疫和过敏性疾病中的重要性。

更新日期:2020-12-15
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