Despite substantial advances in the field of cancer therapeutics, metastasis is a significant challenge for a favorable clinical outcome. Epithelial to mesenchymal transition (EMT) is a process of acquiring increased motility, invasiveness, and therapeutic resistance by cancer cells for their sustained growth and survival. A plethora of intrinsic mechanisms and extrinsic microenvironmental factors drive the process of cancer metastasis. Calcium (Ca2+) signaling plays a critical role in dictating the adaptive metastatic cell behavior comprising of cell migration, invasion, angiogenesis, and intravasation. By modulating EMT, Ca2+ signaling can regulate the complexity and dynamics of events leading to metastasis. This review summarizes the role of Ca2+ signal remodeling in the regulation of EMT and metastasis in cancer.

中文翻译：

---

钙信号在调节上皮间质转化中的作用

尽管癌症治疗领域取得了重大进展，但转移是获得良好临床结果的重大挑战。上皮间质转化 (EMT) 是癌细胞为持续生长和存活而获得增加的运动性、侵袭性和治疗抗性的过程。过多的内在机制和外在的微环境因素驱动着癌症转移的过程。钙 (Ca2+) 信号传导在决定包括细胞迁移、侵袭、血管生成和血管内渗入的适应性转移细胞行为中起关键作用。通过调节 EMT，Ca2+ 信号可以调节导致转移的事件的复杂性和动态。本综述总结了 Ca2+ 信号重构在调节 EMT 和癌症转移中的作用。