Beyond regulations at DNA levels: A review of epigenetic therapeutics targeting cancer stem cells,Cell Proliferation

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Beyond regulations at DNA levels: A review of epigenetic therapeutics targeting cancer stem cells
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-12-13 , DOI: 10.1111/cpr.12963
Shunhao Zhang ₁ , Yanji Gong _{2,

3} , Chunjie Li ₃ , Wenbin Yang ₁ , Longjiang Li ₃

Affiliation

In the past few years, the paramount role of cancer stem cells (CSCs), in terms of cancer initiation, proliferation, metastasis, invasion and chemoresistance, has been revealed by accumulating studies. However, this level of cellular plasticity cannot be entirely explained by genetic mutations. Research on epigenetic modifications as a complementary explanation for the properties of CSCs has been increasing over the past several years. Notably, therapeutic strategies are currently being developed in an effort to reverse aberrant epigenetic alterations using specific chemical inhibitors. In this review, we summarize the current understanding of CSCs and their role in cancer progression, and provide an overview of epigenetic alterations seen in CSCs. Importantly, we focus on primary cancer therapies that target the epigenetic modification of CSCs by the use of specific chemical inhibitors, such as histone deacetylase (HDAC) inhibitors, DNA methyltransferase (DNMT) inhibitors and microRNA-based (miRNA-based) therapeutics.

中文翻译：

超越 DNA 水平的法规：针对癌症干细胞的表观遗传疗法综述

在过去几年中，越来越多的研究揭示了癌症干细胞 (CSC) 在癌症发生、增殖、转移、侵袭和化学抗性方面的重要作用。然而，这种水平的细胞可塑性不能完全用基因突变来解释。在过去几年中，作为对 CSC 特性的补充解释的表观遗传修饰的研究一直在增加。值得注意的是，目前正在开发治疗策略，以使用特定的化学抑制剂来逆转异常的表观遗传改变。在这篇综述中，我们总结了目前对 CSCs 及其在癌症进展中的作用的理解，并概述了 CSCs 中的表观遗传改变。重要的，

更新日期：2020-12-13

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