Recent advances in single‐cell multimodal analysis to study immune cells,Immunology and Cell Biology

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Recent advances in single‐cell multimodal analysis to study immune cells
Immunology and Cell Biology ( IF 3.2 ) Pub Date : 2020-12-14 , DOI: 10.1111/imcb.12432
Raymond Hy Louie ₁ , Fabio Luciani ₁

Affiliation

Recent advances in single‐cell technologies have enabled the profiling of the genome, epigenome, transcriptome and proteome, along with temporal and spatial information of individual cells. These technologies have provided unique opportunities to understand mechanisms underpinning the immune system, such as characterizations of the molecular cell state, how the cell state evolves along its lineage and the impact of spatial location on cell state. In this review, we discuss how these mechanisms have been studied through recent advances in single‐cell multimodal technologies.

中文翻译：

单细胞多模态分析研究免疫细胞的最新进展

单细胞技术的最新进展使得能够分析基因组、表观基因组、转录组和蛋白质组，以及单个细胞的时间和空间信息。这些技术为了解支撑免疫系统的机制提供了独特的机会，例如分子细胞状态的特征、细胞状态如何沿其谱系进化以及空间位置对细胞状态的影响。在这篇综述中，我们讨论了如何通过单细胞多模式技术的最新进展来研究这些机制。

更新日期：2021-02-11

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