Epigallocatechin‐3‐gallate (EGCG), the major polyphenol found in green tea, exerts multiple protective effects against cardiovascular diseases, including cardiac hypertrophy. However, the molecular mechanism underlying its anti‐hypertrophic effect has not been clarified. This study revealed that EGCG could inhibit pressure overload‐induced cardiac hypertrophy by regulating the PSMB5/Nmnat2/SIRT6‐dependent signalling pathway.

中文翻译：

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EGCG 通过 PSMB5/Nmnat2/SIRT6 依赖性信号通路抑制压力超负荷诱导的心脏肥大

表没食子儿茶素-3-没食子酸酯 (EGCG) 是绿茶中的主要多酚，对心血管疾病（包括心脏肥大）具有多种保护作用。然而，其抗肥大作用的分子机制尚未阐明。该研究表明，EGCG 可以通过调节 PSMB5/Nmnat2/SIRT6 依赖性信号通路来抑制压力超负荷诱导的心脏肥大。