Atom Probe Tomography of Encapsulated Hydroxyapatite Nanoparticles,Small Methods

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Atom Probe Tomography of Encapsulated Hydroxyapatite Nanoparticles
Small Methods ( IF 10.7 ) Pub Date : 2020-12-13 , DOI: 10.1002/smtd.202000692
Daniel S Mosiman _{1,

2} , Yi-Sheng Chen _{1,

3} , Limei Yang ₁ , Brian Hawkett ₄ , Simon P Ringer _{1,

3} , Benito J Mariñas ₂ , Julie M Cairney _{1,

3}

Affiliation

Hydroxyapatite nanoparticles (HAP NPs) are important for medicine, bioengineering, catalysis, and water treatment. However, current understanding of the nanoscale phenomena that confer HAP NPs their many useful properties is limited by a lack of information about the distribution of the atoms within the particles. Atom probe tomography (APT) has the spatial resolution and chemical sensitivity for HAP NP characterization, but difficulties in preparing the required needle‐shaped samples make the design of these experiments challenging. Herein, two techniques are developed to encapsulate HAP NPs and prepare them into APT tips. By sputter‐coating gold or the atomic layer deposition of alumina for encapsulation, partially fluoridated HAP NPs are successfully characterized by voltage‐ or laser‐pulsing APT, respectively. Analyses reveal that significant tradeoffs exist between encapsulant methods/materials for HAP characterization and that selection of a more robust approach will require additional technique development. This work serves as an essential starting point for advancing knowledge about the nanoscale spatiochemistry of HAP NPs.

中文翻译：

包封羟基磷灰石纳米粒子的原子探针断层扫描

羟基磷灰石纳米粒子 (HAP NPs) 对于医学、生物工程、催化和水处理非常重要。然而，目前对赋予 HAP NPs 许多有用特性的纳米级现象的理解受到缺乏关于粒子内原子分布的信息的限制。原子探针断层扫描 (APT) 具有用于 HAP NP 表征的空间分辨率和化学敏感性，但制备所需针状样品的困难使得这些实验的设计具有挑战性。在这里，开发了两种技术来封装 HAP NP 并将它们准备成 APT 尖端。通过溅射镀金或氧化铝原子层沉积进行封装，部分氟化的 HAP NPs 分别成功地通过电压或激光脉冲 APT 进行了表征。分析表明，用于 HAP 表征的封装方法/材料之间存在重大权衡，选择更稳健的方法将需要额外的技术开发。这项工作是推进有关 HAP NPs 纳米尺度空间化学知识的重要起点。

更新日期：2021-02-12

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