Micro‐/Nano‐Structures on Biodegradable Magnesium@PLGA and Their Cytotoxicity, Photothermal, and Anti‐Tumor Effects,Small Methods

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Micro‐/Nano‐Structures on Biodegradable Magnesium@PLGA and Their Cytotoxicity, Photothermal, and Anti‐Tumor Effects
Small Methods ( IF 10.7 ) Pub Date : 2020-12-13 , DOI: 10.1002/smtd.202000920
Weixiao Zhou ₁ , Yinling Zhang ₁ , Si Meng ₁ , Chenyang Xing ₂ , Mingze Ma ₁ , Zhou Liu ₃ , Chengbin Yang ₁ , Tiantian Kong ₁

Affiliation

The size and structural control of particulate carriers for imaging agents and therapeutics are constant themes in designing smart delivery systems. This is motivated by the causal relationship between geometric parameters and functionalities of delivery vehicles. Here, both in vitro and in vivo, the controlling factors for cytotoxicity, photothermal, and anti‐tumor effects of biodegradable magnesium@poly(lactic‐co‐glycolic acid (Mg@PLGA) particulate carriers with different sizes and shell thicknesses are investigated. Mg@PLGA microspheres fabricated by microfluidic emulsification are shown to have higher Mg encapsulation efficiency, 87%, than nanospheres by ultrasonic homogenization, 50%. The photothermal and anti‐tumor effects of Mg@PLGA spheres are found to be dictated by their Mg content, irrelevant to size and structural features, as demonstrated in both in vitro cell assays and in vivo mice models. These results also provide important implications for designing and fabricating stimuli‐responsive drug delivery vehicles.

中文翻译：

可生物降解镁@PLGA的微/纳米结构及其细胞毒性、光热和抗肿瘤作用

用于显像剂和治疗剂的颗粒载体的尺寸和结构控制是设计智能递送系统的不变主题。这是由运载工具的几何参数和功能之间的因果关系推动的。在这里，在体外和体内，研究了不同尺寸和壳厚度的可生物降解镁@聚（乳酸-共-乙醇酸（Mg@PLGA）颗粒载体的细胞毒性、光热和抗肿瘤作用的控制因素。通过微流控乳化制备的 Mg@PLGA 微球的 Mg 包封率为 87%，高于超声均质法制备的 50%。，与尺寸和结构特征无关，正如体外细胞试验和体内小鼠模型所证明的那样。这些结果也为设计和制造刺激响应的药物输送载体提供了重要的启示。

更新日期：2021-02-12

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