The objective of the present study was to evaluate the renal function of rural workers in a city of northeastern Brazil. A cross‐sectional study was carried out with 208 workers in Boquim, Sergipe, Brazil. Renal function markers and butyrylcholinesterase (BChE) were evaluated and the glomerular filtration rate (GFR) was determined. The sample consisted mainly of illiterate males with a low usage of personal protective equipment and no training. Approximately 40% had some level of renal failure. Relative risk (1.59) of GFR alteration was higher in workers with more than 5 yr of exposure, mainly to organophosphates. Workers more than 60 yr of age presented a 17.06 greater risk for manifesting acute intoxication. Butyrylcholinesterase reduction was associated with reports of intoxication (relative risk of 11.36). We concluded that exposure to pesticides represented a risk factor for the development of nephrotoxic effects and alteration of renal function, which reinforced the need to implement measures to protect rural workers. Environ Toxicol Chem 2021;40:1132–1138. © 2020 SETAC

中文翻译：

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巴西东北部地区职业接触农用化学品引起的肾毒性影响：一项横断面研究

本研究的目的是评估巴西东北部城市农村工人的肾功能。在巴西塞尔希佩的 Boquim 对 208 名工人进行了一项横断面研究。评估肾功能标志物和丁酰胆碱酯酶 (BChE) 并测定肾小球滤过率 (GFR)。样本主要由不识字的男性组成，他们很少使用个人防护设备，也没有接受过培训。大约 40% 有一定程度的肾功能衰竭。GFR 改变的相对风险（1.59）在接触超过 5 年的工人中较高，主要是有机磷酸盐。60 岁以上的工人出现急性中毒的风险高出 17.06。丁酰胆碱酯酶减少与中毒报告相关（相对风险为 11.36）。环境毒物化学2021；40:1132–1138。© 2020 SETAC