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Effect of Non‐volatile Constituents of Elsholtzia ciliata (Thunb.) Hyl. from Northern Vietnam on Reactive Oxygen Species and Nitric Oxide Release in Macrophages
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-12-17 , DOI: 10.1002/cbdv.202000577
Dieu T X Nguyen 1, 2 , Hung Tran 1 , Stefan Schwaiger 2 , Hermann Stuppner 2 , Stefania Marzocco 3
Affiliation  

The extract of Elsholtzia ciliata aerial parts was subjected to bio‐guided isolation using the intercellular ROS reduction in J774A.1 macrophages to monitor the anti‐oxidative activity. Fifteen compounds were isolated from the active fractions including eleven flavonoids (vitexin, pedalin, luteolin‐7‐O‐β‐d‐glucopyranoside, apigenin‐5‐O‐β‐d‐glucopyranoside, apigenin‐7‐O‐β‐d‐glucopyranoside, chrysoeriol‐7‐O‐β‐d‐glucopyranoside, 7,3′‐dimethoxyluteolin‐6‐O‐β‐d‐glucopyranoside, luteolin, 5,6,4′‐trihydroxy‐7,3′‐dimethoxyflavone, 5‐hydroxy‐6,7‐dimethoxyflavone (compound 13), 5‐hydroxy‐7,8‐dimethoxyflavone); three hydroxycinnamic acid derivatives (caffeic acid, 4‐(E)‐caffeoyl‐l‐threonic acid, 4‐O‐(E)‐p‐coumaroyl‐l‐threonic acid) and one fatty acid (α‐linolenic acid). The biological evaluation of these compounds (10–2.5 μm) indicated that all of them exerted good antioxidant and anti‐inflammatory activities, in particular compound 13.

中文翻译:

Elsholtzia ciliata (Thunb.) Hyl 非挥发性成分的影响。来自越南北部关于巨噬细胞中活性氧种类和一氧化氮释放的研究

使用 J774A.1 巨噬细胞中的细胞间 ROS 减少对香薷地上部分的提取物进行生物引导分离,以监测抗氧化活性。从活性组分中分离出 15 种化合物,包括 11 种黄酮类化合物(牡荆素、脚踏蛋白、木犀草素-7-O-β-d-吡喃葡萄糖苷、芹菜素-5-O-β-d-吡喃葡萄糖苷、芹菜素-7-O-β-d-吡喃葡萄糖苷, chrysoeriol-7-O-β-d-吡喃葡萄糖苷, 7,3'-二甲氧基木犀草素-6-O-β-d-吡喃葡萄糖苷, 木犀草素, 5,6,4'-三羟基-7,3'-二甲氧基黄酮, 5 -羟基-6,7-二甲氧基黄酮(化合物13),5-羟基-7,8-二甲氧基黄酮);三种羟基肉桂酸衍生物(咖啡酸、4-(E)-咖啡酰-l-苏糖酸、4-O-(E)-对香豆酰-l-苏糖酸)和一种脂肪酸(α-亚麻酸)。这些化合物的生物学评价 (10-2.
更新日期:2020-12-17
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