The Reduced Uterine Perfusion Pressure (RUPP) rat model of placental ischemia recapitulates many characteristics of preeclampsia including maternal hypertension, intrauterine growth restriction (IUGR), and increased cytolytic natural killer cells (cNKs). While we have previously shown a 5‐fold higher cytotoxicity of RUPP NKs versus normal pregnant NKs, their role in RUPP pathophysiology remains unclear. In this study, we tested the hypotheses that (1) adoptive transfer of RUPP‐stimulated NKs will induce maternal hypertension and IUGR in normal pregnant control (Sham) rats and (2) adoptive transfer of Sham NKs will attenuate maternal hypertension and IUGR in RUPP rats.

中文翻译：

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胎盘缺血刺激的自然杀伤细胞的过继转移导致妊娠大鼠出现先兆子痫样表型


胎盘缺血的子宫灌注压降低 (RUPP) 大鼠模型概括了先兆子痫的许多特征，包括母体高血压、宫内生长受限 (IUGR) 和溶细胞性自然杀伤细胞 (cNK) 增加。虽然我们之前已经证明 RUPP NK 的细胞毒性比正常妊娠 NK 高 5 倍，但它们在 RUPP 病理生理学中的作用仍不清楚。在这项研究中，我们测试了以下假设：(1) RUPP 刺激的 NK 的过继转移将在正常妊娠对照 (Sham) 大鼠中诱发孕产妇高血压和 IUGR；(2) 过继转移 Sham NK 会减轻 RUPP 中的孕产妇高血压和 IUGR老鼠。