Background

Human biomonitoring studies of trace elements in biological fluids are mostly limited to a certain number of elements or biological materials. In this study, we describe the significant extension of a biomonitoring to 73 elements being present in concentration ranges from ng/L to g/L in clinically relevant specimens such as blood, serum, erythrocytes and urine.

Methods

The samples were collected from 102 occupationally non-exposed inhabitants of northern Germany. The elements were determined either by inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) in the low concentration range or by inductively coupled plasma optical emission spectrometry (ICP-OES) for essential trace elements and electrolytes.

Results

Mean values and selected percentiles of element concentrations are presented for all sample materials. From the results, we calculated the distribution of elements between plasma and blood cells. Application of ICP-MS/MS improves selectivity and accuracy in the determination of elements that are strongly spectrally interfered, such as Cr, Ge, Pd or Ti in blood samples.

Conclusions

This publication provides very valuable information for occupational or environmental hygienists, toxicologists and clinical chemists due to the particularly high number of determined elements and presented concentration ranges.

中文翻译：

---

人体对血液、血清、红细胞和尿液中 73 种元素的生物监测

背景

人体对生物体液中微量元素的生物监测研究大多限于一定数量的元素或生物材料。在这项研究中，我们描述了对 73 种元素的生物监测的显着扩展，这些元素在临床相关样本（如血液、血清、红细胞和尿液）中的浓度范围从 ng/L 到 g/L。

方法

样本是从德国北部的 102 名职业非暴露居民收集的。元素通过电感耦合等离子体串联质谱法 (ICP-MS/MS) 在低浓度范围内或通过电感耦合等离子体发射光谱法 (ICP-OES) 测定必需的痕量元素和电解质。

结果

所有样品材料都提供了元素浓度​​的平均值和选定的百分位数。根据结果​​，我们计算了血浆和血细胞之间的元素分布。ICP-MS/MS 的应用提高了测定受到强烈光谱干扰的元素（如血样中的 Cr、Ge、Pd 或 Ti）的选择性和准确度。

结论

该出版物为职业或环境卫生学家、毒理学家和临床化学家提供了非常有价值的信息，因为确定的元素数量和所呈现的浓度范围特别多。