We report the first case of pineoblastoma in a cow. At necropsy, a soft, gelatinous greyish yellow, 4 × 3 × 2 cm mass was found midsagittally on the dorsal surface of the midbrain. The mass enveloped the brainstem anterior to the cerebellum, extended to the pituitary fossa and was adherent to the ventromedial aspect of the occipital lobes. Histologically, the mass was unencapsulated, with extramedullary proliferation into the lobes and meninges, but was demarcated from the adjacent brain tissue. Histological findings were consistent with a pineoblastoma, as reported in other species, and the neoplasm was strongly immunopositive for synaptophysin. Glial fibrillary acidic protein-positive spindloid astrocytic processes surrounded blood vessels and extended around neoplastic cells.

我们报告了一头母牛的松果体母细胞瘤病例。尸检时，在中脑背侧正中矢状面发现一个柔软的、凝胶状的灰黄色、4×3×2厘米的肿块。肿块包绕小脑前方的脑干，延伸至垂体窝并附着于枕叶的腹内侧。组织学上，肿块没有包膜，髓外增生进入脑叶和脑膜，但与相邻的脑组织分界。组织学发现与其他物种中报道的松果体母细胞瘤一致，并且该肿瘤对突触素呈强免疫阳性。胶质纤维酸性蛋白阳性纺锤体星形胶质细胞突起围绕血管并在肿瘤细胞周围延伸。