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Mitochondria in Their Prime Drive Venetoclax Response in Acute Myeloid Leukemia
Cancer Cell ( IF 50.3 ) Pub Date : 2020-12-14 , DOI: 10.1016/j.ccell.2020.10.018
Mette C. Kriegbaum , Krister Wennerberg

Venetoclax has changed the clinical outlook for elderly and unfit patients with acute myeloid leukemia, but development of resistance is a challenge. In this issue of Cancer Cell, Bhatt et al. provide a general mechanism for how resistance emerges but also indications for how venetoclax-resistant cases may be treated.



中文翻译:

线粒体在急性髓性白血病中的主要驱动性静脉曲张反应中。

Venetoclax改变了老年和不适合的急性髓性白血病患者的临床前景,但耐药性的发展是一个挑战。在本期《癌细胞》中,Bhatt等人。提供了产生抗药性的一般机制,同时也提供了如何治疗耐静脉曲张的病例的迹象。

更新日期:2020-12-14
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