Using targeted single-cell DNA sequencing approaches, two articles in Nature and Nature Communications have now firmly established that acute myeloid leukemia is a highly dynamic oligoclonal disease. Clonal evolution during disease progression and therapy occurs in both linear and branched trajectories, with a clear order of mutational events.

中文翻译：

---

剖析 AML 中的克隆异质性

使用靶向单细胞 DNA 测序方法，《自然》和《自然通讯》上的两篇文章现已明确证实急性髓系白血病是一种高度动态的寡克隆疾病。疾病进展和治疗期间的克隆进化以线性和分支轨迹发生，具有明确的突变事件顺序。