Abstract Two new cobalt(II) cluster-based 3D coordination polymers [Co 2 (MeOip) 2 (bpa) 2 (H 2 O)] ( 1 ) and [Co 5 (MeOip) 4 (μ 3 -O)(bpp) 2 (DMF)(H 2 O) 3 ]·2H 2 O ( 2 ) (MeOip = 5-methoxyisophthalate, bpp = 1,3-bis(4-pyridyl)propane and bpa = 1,2-bi(4-pyridyl)ethane) are synthesized with 5-methoxyisophthalic acid and bpp/bpa mixed ligands. Furthermore, the prevention activity of the compounds on skin necrosis after fracture and its mechanism is evaluated. Firstly, the content level of MCSF and TNF-α is evaluated with the ELISA detection kit. The relative expression level of MMP2 and TIMP1 is measured with real-time RT-PCR.

中文翻译：

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两种基于 Co(II) 的配位聚合物：结构多样性和对骨折和内固定后皮肤坏死的预防作用

摘要 两种新的基于钴 (II) 簇的 3D 配位聚合物 [Co 2 (MeOip) 2 (bpa) 2 (H 2 O)] ( 1 ) 和 [Co 5 (MeOip) 4 (μ 3 -O)(bpp) 2 (DMF)(H 2 O) 3 ]·2H 2 O ( 2 ) (MeOip = 5-甲氧基间苯二甲酸酯，bpp = 1,3-双(4-吡啶基)丙烷和 bpa = 1,2-双(4-吡啶基) )乙烷) 是用 5-甲氧基间苯二甲酸和 bpp/bpa 混合配体合成的。此外，评价了化合物对骨折后皮肤坏死的预防作用及其机制。首先用ELISA检测试剂盒评价MCSF和TNF-α的含量水平。MMP2 和 TIMP1 的相对表达水平用实时 RT-PCR 测量。