Introduction: Because of its high morbidity and mortality, sepsis remains the leading cause of death in the ICU. Microparticles (MP) have been largely studied as potential diagnostic or prognostic markers in various diseases including sepsis.
Objective: The biological and clinical relevance of neutrophil-derived microparticles (NDMPs) within the MP population remains unclear. The objective of this study was to elucidate the relationship between plasma NDMPs and the prognosis of patients with sepsis and/or septic shock.
Methods: The study was designed as an observational, noninterventional clinical study. The cohort for this study included 40 sepsis and 40 septic shock patients together with 10 healthy controls admitted to the Intensive Care Unit (ICU) and the Health Surveillance Center in the Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, from January to November 2018, respectively. The degree of critical disease for sepsis and septic shock was evaluated, with data analyses conducted from 2018 to 2019.
Results: On days 1, 3 and 5 post-admission a series of data including plasma NDMP levels, patient demographics, TNF-α levels, IL-6 levels, sTREM-1 levels, and the sepsis severity score measurements were collected. A survival curve was plotted against levels of plasma NDMPs. Levels of NDMPs were observed to be higher in the septic shock patients than in the sepsis patients on days 1, 3, and 5 post-ICU admission (p < 0.05). NDMP levels were significantly increased in sepsis and septic shock patients with a parallel increase in pro-inflammatory mediators and sepsis severity score (p < 0.05) as well as mortality.
Conclusion: Our data suggest that NDMPs may be a biomarker of sepsis severity and mortality although its implications on sepsis prognosis warrant further study.

Keywords: sepsis, septic shock, cell-derived microparticles, biomarker, prognosis


中文翻译：

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与脓毒症患者预后相关的循环中性粒细胞衍生微粒

简介：由于其高发病率和死亡率，脓毒症仍然是 ICU 死亡的主要原因。微粒 (MP) 已被广泛研究为包括败血症在内的各种疾病的潜在诊断或预后标志物。
目的：中性粒细胞衍生微粒 (NDMP) 在 MP 人群中的生物学和临床相关性仍不清楚。本研究的目的是阐明血浆 NDMP 与脓毒症和/或脓毒性休克患者预后之间的关系。
方法：该研究被设计为一项观察性、非介入性临床研究。本研究的队列包括 40 名脓毒症患者和 40 名感染性休克患者以及 10 名健康对照者，于 1 月至分别是 2018 年 11 月。对脓毒症和脓毒性休克的危重疾病程度进行了评估，并进行了 2018 年至 2019 年的数据分析。
结果：在入院后第 1、3 和 5 天，收集了一系列数据，包括血浆 NDMP 水平、患者人口统计学、TNF-α 水平、IL-6 水平、sTREM-1 水平和脓毒症严重程度评分测量值。针对血浆 NDMP 水平绘制存活曲线。在入住 ICU 后第 1、3 和 5 天，感染性休克患者的 NDMP 水平高于脓毒症患者（p < 0.05）。脓毒症和脓毒性休克患者的 NDMP 水平显着增加，促炎介质和脓毒症严重程度评分 ( p < 0.05) 以及死亡率平行增加。
结论：我们的数据表明，NDMPs 可能是脓毒症严重程度和死亡率的生物标志物，尽管其对脓毒症预后的影响值得进一步研究。

关键词：脓毒症，脓毒性休克，细胞衍生微粒，生物标志物，预后