Abstract

Among the most used carriers for pharmaceutical and cosmetic purposes, niosomes are biocompatible and versatile systems, capable of enhance the therapeutic effects of encapsulated drugs for topical and transdermal treatments. Overall, the nanometer size and flexibility of these systems can improve the skin penetration and permeation of several drugs, but the suspension obtained after their preparation does not present the required rheological properties for topical use. Polymeric hydrogels can be employed, since they are compatible, and ease made, maintaining the integrity of nanostructures, besides promoting suitable formulation viscosity and spreadability. Therefore, this association can affect topical formulation properties, depending on the polymer type, purity, cross-links density, and by the electrostatic interactions between polymer and vesicle surface charges.

摘要

在药物和化妆品用途最常用的载体中，niosomes 是生物相容性和多功能系统，能够增强包封药物在局部和经皮治疗中的治疗效果。总体而言，这些系统的纳米尺寸和柔韧性可以提高几种药物的皮肤渗透性和渗透性，但制备后获得的悬浮液不具备局部使用所需的流变特性。可以使用聚合物水凝胶，因为它们是相容的，并且易于制造，保持纳米结构的完整性，除了促进合适的配方粘度和铺展性。因此，这种关联会影响局部制剂的性质，具体取决于聚合物类型、纯度、交联密度、