Abstract

Stimuli responsive nanocarriers proved to be an efficient system in accurate diagnosis and targeted delivery of therapeutic moieties. Enzymes have been researched widely as successful targeting agents among various endogenous and exogenous stimuli responsive systems and employed as bio-nanotechnological tool due to their intrinsic presence, higher specificity and catalytic action in various biological processes. Nanosystems are fabricated possessing unique responsiveness toward enzymes that are elevated at pathological sites leading to targeted release of drugs at diseased site. This review discusses various enzymes and explores recently developed nanocarriers responsive to enzymes with versatile extracellular and intracellular drug delivery applications.

摘要

刺激响应纳米载体被证明是准确诊断和靶向递送治疗部分的有效系统。酶因其固有的存在、更高的特异性和在各种生物过程中的催化作用而被广泛研究为各种内源性和外源性刺激响应系统中的成功靶向剂，并被用作生物纳米技术工具。制造的纳米系统对在病理部位升高的酶具有独特的反应性，从而导致药物在病变部位的靶向释放。这篇综述讨论了各种酶，并探索了最近开发的对酶有反应的纳米载体，具有多种细胞外和细胞内药物递送应用。