Reactivity of Flavonoids Containing a Catechol or Pyrogallol Moiety with Metal‐Free and Metal‐Associated Amyloid‐β,Bulletin of the Korean Chemical Society

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Reactivity of Flavonoids Containing a Catechol or Pyrogallol Moiety with Metal‐Free and Metal‐Associated Amyloid‐β
Bulletin of the Korean Chemical Society ( IF 2.3 ) Pub Date : 2020-12-13 , DOI: 10.1002/bkcs.12172
Seongmin Park ₁ , Yelim Yi ₁ , Mi Hee Lim ₁

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Aggregates of both metal‐free amyloid‐β (Aβ) and metal‐bound Aβ (metal–Aβ) are accumulated in the brain affected by Alzheimer's disease. To control metal‐free and metal‐bound Aβ species, chemical reagents capable of modulating their aggregation profiles have been developed. As an effort, the reactivity of natural products such as flavonoids with metal‐free Aβ and metal–Aβ has been investigated to identify their use as chemical reagents and structural features essential for such reactivity. This review illustrates the effects of flavonoids containing a catechol or pyrogallol group on metal‐free and metal‐mediated Aβ aggregation pathways. In addition, the studies regarding the structure–activity relationship of flavonoids against metal‐free Aβ or metal–Aβ are discussed.

中文翻译：

含有邻苯二酚或邻苯三酚部分的类黄酮与无金属和与金属相关的淀粉样β的反应性

无金属的淀粉样β（Aβ）和金属结合的Aβ（metal-Aβ）的聚集物在受阿尔茨海默氏病影响的大脑中积累。为了控制无金属和与金属结合的Aβ物种，已经开发了能够调节其聚集曲线的化学试剂。作为一项努力，已经研究了天然产物（如类黄酮）与无金属的Aβ和金属的Aβ的反应性，以鉴定其作为化学试剂的用途和对该反应性必不可少的结构特征。这篇综述说明了含有邻苯二酚或邻苯三酚基团的类黄酮对无金属和金属介导的Aβ聚集途径的影响。此外，还讨论了有关类黄酮对无金属Aβ或金属Aβ的结构-活性关系的研究。

更新日期：2021-01-27

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