Industrial biotechnology faces the challenge of providing significant economic advantages using sustainable processes either to establish new processes, to displace established processes or valorize industrial waste. Crude glycerol obtained as a by-product of biodiesel production has very low market value but can be valorized via microbial bioconversions. This work revises efforts made by the scientific community to optimize the crude glycerol microbial biotransformation into dihydroxyacetone, one of the most valuable compounds obtained from this feedstock. Attention to the many aspects of process optimization to increase productivity has been addressed that are also transversal to other glycerol biotransformations to obtain improved yields.

工业生物技术面临的挑战是，利用可持续流程来建立新流程，替代既定流程或对工业废物进行增值，从而提供重大的经济优势。作为生物柴油生产的副产品获得的粗制甘油的市场价值非常低，但可以通过微生物的生物转化来实现增值。这项工作修改了科学界为优化粗制甘油微生物向二羟基丙酮的生物转化所做的努力，二羟基丙酮是从这种原料中获得的最有价值的化合物之一。已经解决了对提高生产率的过程优化的许多方面的关注，这些方面也横向于其他甘油生物转化以获得提高的产率。