Anthelmintic drugs are the major line of defense against parasitic nematode infections, but the arsenal is limited and resistance threatens sustained efficacy of the available drugs. Discoveries of the modes of action of these drugs and mechanisms of resistance have predominantly come from studies of a related nonparasitic nematode species, Caenorhabditis elegans, and the parasitic nematode Haemonchus contortus. Here, we discuss how our understanding of anthelmintic resistance and modes of action came from the interplay of results from each of these species. We argue that this 'cycle of discovery', where results from one species inform the design of experiments in the other, can use the complementary strengths of both to understand anthelmintic modes of action and mechanisms of resistance.

驱虫药物是抵抗寄生虫线虫感染的主要防线，但其武器库有限，耐药性威胁到可用药物的持续疗效。这些药物的作用方式和耐药机制的发现主要来自对相关的非寄生线虫种类、秀丽隐杆线虫和寄生线虫扭曲血矛线虫的研究。在这里，我们讨论了我们对驱虫药抗性和作用方式的理解如何来自这些物种的结果的相互作用。我们认为，这种“发现循环”，其中一个物种的结果为另一个物种的实验设计提供信息，可以利用两者的互补优势来了解驱虫的作用模式和抗性机制。