Seven organotin(IV) complexes, [(R₃Sn)₂L]_n (R = Me 1, R = n-Bu 2), [(Ph₃Sn)₂L] (3), [(R₂Sn)₂L(μ₃-O)]_n (R = Me 4, R = n-Bu 5), [R₂SnL(1,10-phen)]_n (R = Me 6), [(R₂SnCl)₂L(1,10-phen)₂] (R = n-Bu 7) derived from 1,4-naphthalenedicarboxylic acid (H₂L) have been synthesized and characterized by elemental analysis, FT-IR, PXRD, NMR and X-ray crystallography. The single crystal diffraction reveals that complexes 1 and 2 represent 2D network structures, which both contain tetranuclear 26-membered macrocycles. Complexes 3 and 7 display dinuclear tin monomers, which can form 1D infinite chain by C-H•••O and C-H•••π interactions. Meanwhile, complexes 4 and 5 display 2D network containing tetraorganodistannoxane unit, while complex 6 adopts a 1D infinite chain structure, which further constructs 2D supramolecular architecture through C-H•••O intermolecular interactions. What's more, in vitro cytostatic activity of the complexes 1-3 against cervical carcinoma cell lines (HeLa), hepatocellular carcinoma cell lines (HepG-2) and human normal breast cell lines (HBL-100) have been investigated, and the results show that organotin derivatives with n-butyl and phenyl group (2 and 3) exhibit significantly higher anticancer activity than complex 1 with methyl group. Meanwhile, organotin(IV) complexes (1-3) display lower cytotoxicity than corresponding organotin(IV) precursors [trimethyltin chloride, bis(tri-n-butyltin) oxide and triphenyltin chloride] in HBL-100 cells. Furthermore, cytostatic assessments of complex 3 against HepG-2 cells reveal that the effect of cytostatic and apoptotic may through ROS-mediated pathway.

七个有机锡（IV）配合物，[（R ₃ Sn）₂ L] _n（R = Me 1，R =  n -Bu 2），[（Ph ₃ Sn）₂ L]（3），[（R ₂ Sn）₂ L（μ ₃ -O）] _ñ（R =我4，R =  ñ -Bu 5），[R ₂ SNL（1,10 -苯基）] _ñ（R =我6），[（R ₂的SnCl）₂ L（1,10-phen）₂ ]（R =  n -Bu 7合成了由1,4-萘二甲酸（H ₂ L ）衍生的），并通过元素分析，FT-IR，PXRD，NMR和X射线晶体学表征。单晶衍射揭示复合物1和2代表2D网络结构，都包含四核26元大环。配合物3和7显示双核锡单体，它们可以通过CH ••• O和CH ••• π相互作用形成一维无限链。同时，配合物4和5显示包含四有机二锡氧烷单元的2D网络，而配合物6采用一维无限链结构，可通过CH ••• O分子间相互作用进一步构建2D超分子体系。更重要的是，在体外的复合物的细胞生长抑制活性1 - 3对宫颈癌细胞系（HeLa细胞），肝癌细胞株（人肝癌HepG-2）和人正常乳腺细胞系（HBL-100）进行了调查，结果表明具有正丁基和苯基基团（2和3）的有机锡衍生物显示出比具有甲基的配合物1高得多的抗癌活性。同时，有机锡（IV）配合物（1 - 3）显示比相应的有机锡（IV）的前体[三甲基氯化锡，双（三-低毒性Ñ在HBL-100细胞-butyltin）氧化物和三苯基氯化锡。此外，针对HepG-2细胞的复合物3的细胞生长抑制作用评估表明，细胞生长抑制作用和细胞凋亡作用可能是通过ROS介导的途径引起的。