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Comparison of the efficacy of metagenomic next-generation sequencing and Xpert MTB/RIF in the diagnosis of tuberculous meningitis
Journal of Microbiological Methods ( IF 1.7 ) Pub Date : 2020-12-13 , DOI: 10.1016/j.mimet.2020.106124
Guocan Yu 1 , Xiaodan Wang 2 , Pengfei Zhu 1 , Yanqin Shen 1 , Wuchen Zhao 1 , Lihong Zhou 1
Affiliation  

Metagenomic next-generation sequencing (mNGS) is an emerging sequence-based method that detects genomic information of pathogenic microorganisms from a wide range of clinical specimens. The mNGS has moderate sensitivity and very high specificity for tuberculous meningitis, and the validity of mNGS was higher than that of Xpert MTB/RIF.



中文翻译:

宏基因组二代测序与Xpert MTB/RIF在结核性脑膜炎诊断中的疗效比较

宏基因组二代测序(mNGS)是一种新兴的基于序列的方法,可从广泛的临床标本中检测病原微生物的基因组信息。mNGS对结核性脑膜炎具有中等敏感性和极高特异性,mNGS的有效性高于Xpert MTB/RIF。

更新日期:2020-12-16
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