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Genome-wide translation patterns in gliomas: An integrative view
Cellular Signalling ( IF 4.4 ) Pub Date : 2020-12-13 , DOI: 10.1016/j.cellsig.2020.109883
Glaucia Noeli Maroso Hajj 1 , Paula Borzino Cordeiro Nunes 2 , Martin Roffe 1
Affiliation  

Gliomas are the most frequent tumors of the central nervous system (CNS) and include the highly malignant glioblastoma (GBM). Characteristically, gliomas have translational control deregulation related to overactivation of signaling pathways such as PI3K/AKT/mTORC1 and Ras/ERK1/2. Thus, mRNA translation appears to play a dominant role in glioma gene expression patterns. The, analysis of genome-wide translated transcripts, together known as the translatome, may reveal important information for understanding gene expression patterns in gliomas. This review provides a brief overview of translational control mechanisms altered in gliomas with a focus on the current knowledge related to the translatomes of glioma cells and murine glioma models. We present an integrative meta-analysis of selected glioma translatome data with the aim of identifying recurrent patterns of gene expression preferentially regulated at the level of translation and obtaining clues regarding the pathological significance of these alterations. Re-analysis of several translatome datasets was performed to compare the translatomes of glioma models with those of their non-tumor counterparts and to document glioma cell responses to radiotherapy and MNK modulation. The role of recurrently altered genes in the context of translational control and tumorigenesis are discussed.



中文翻译:

神经胶质瘤中的全基因组翻译模式:综合观点

胶质瘤是中枢神经系统 (CNS) 最常见的肿瘤,包括高度恶性的胶质母细胞瘤 (GBM)。典型地,胶质瘤具有与信号通路过度激活相关的翻译控制失调,例如 PI3K/AKT/mTORC1 和 Ras/ERK1/2。因此,mRNA 翻译似乎在神经胶质瘤基因表达模式中起主导作用。对全基因组翻译转录本的分析,统称为翻译组,可能会揭示了解神经胶质瘤中基因表达模式的重要信息。本综述简要概述了神经胶质瘤中改变的翻译控制机制,重点介绍了与神经胶质瘤细胞的翻译组和小鼠神经胶质瘤模型相关的当前知识。对几个翻译组数据集进行了重新分析,以将神经胶质瘤模型的翻译组与其非肿瘤模型的翻译组进行比较,并记录神经胶质瘤细胞对放射治疗和 MNK 调制的反应。讨论了在翻译控制和肿瘤发生中反复改变的基因的作用。

更新日期:2020-12-22
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