Aim. Ovarian cancer is a common malignant tumor of the gynecological oncology worldwide, with a high incidence and mortality rate and poor prognosis. Searching for new diagnostic molecular biomarkers for ovarian cancer is extremely significant. Methods. Here, we analyzed the expression rates of eIF4E and cyclin D1 proteins in 123 cases of cancer tissue samples and 38 cases of paracancerous tissue samples and studied the connection between the expression rates of eIF4E and cyclin D1 proteins by immunohistochemistry and statistically correlated with clinicopathological features in ovarian cancer. Results. The results showed that the expression rates of eIF4E and cyclin D1 proteins in ovarian cancer tissues were significantly higher than those in noncancerous epithelial ovarian tissues ( and , respectively). Additionally, the results revealed that a higher expression rate of eIF4E () was found in the advanced stage (stage III/IV), and also patients with cervical lymph node metastasis displayed higher expression of eIF4E () and cyclin D1 () than those without lymph node metastasis. Spearman’s rank correlation test showed that there was a significant positive correlation between the eIF4E and cyclin D1 proteins in ovarian cancer. The Kaplan-Meier method showed that patients with lower expression of eIF4E had marginally better survival than those with high expression of eIF4E (). Multivariate Cox regression analysis further identified that positive expression of eIF4E was an independent prognostic factor. Conclusion. In ovarian cancer, eIF4E might be a valuable biomarker to predict poor prognoses and a potential therapeutic target to develop valid treatment strategies.

中文翻译：

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eIF4E 过度表达与卵巢癌预后不良有关

瞄准。卵巢癌是世界范围内妇科肿瘤的常见恶性肿瘤，发病率和死亡率高，预后差。寻找新的卵巢癌诊断分子生物标志物具有极其重要的意义。方法。在这里，我们分析了 123 例癌组织样本和 38 例癌旁组织样本中 eIF4E 和 cyclin D1 蛋白的表达率，并通过免疫组织化学研究了 eIF4E 和 cyclin D1 蛋白的表达率之间的联系，并与临床病理特征具有统计学相关性。卵巢癌。结果. 结果显示，eIF4E和cyclin D1蛋白在卵巢癌组织中的表达率明显高于非癌性上皮卵巢组织。和，分别）。此外，结果显示 eIF4E 的表达率更高（）在晚期（III/IV期）中发现，并且颈部淋巴结转移的患者表现出更高的eIF4E表达（)和细胞周期蛋白 D1 ()较无淋巴结转移者。Spearman秩相关检验显示卵巢癌中eIF4E与cyclin D1蛋白呈显着正相关。Kaplan-Meier 方法显示，eIF4E 低表达患者的生存率略高于 eIF4E 高表达患者。）。多变量 Cox 回归分析进一步确定 eIF4E 的阳性表达是一个独立的预后因素。结论。在卵巢癌中，eIF4E 可能是预测不良预后的有价值的生物标志物，也是制定有效治疗策略的潜在治疗靶点。