ABSTRACT

This study evaluated the anti-diabetic and hepatic protective effect of the aqueous extract of the Aloe perryi (AP) in streptozotocin-induced diabetic rats. Rat were divided into control, diabetic, diabetic + glimepiride, diabetic + AP (150 or 300 mg/Kg) groups. AP (300 mg/Kg) alone lowered fasting serum glucose levels but increased insulin levels and HOMA-β. At both doses, AP significantly decreased hepatic levels of CHOL and LDL-C and reduced serum levels of TGs, CHOL, and LDL-C, without altering levels of HDL-C in the diabetic rats. Also, they improved liver architectures and reduced serum levels of ALT and AST. Concomitantly, they suppressed hepatic levels of MDA, and increase hepatic levels of SOD, GSH, CAT, and GPx. Except for lipids, the effect of the extract on all other parameters was more profound with the higher dose of the extract. In conclusion, AP extract exerts hypoglycaemic, insulin-releasing, and hepatic antioxidant potentials in diabetic rats.

摘要

这项研究评估了芦荟水提取物的抗糖尿病和肝脏保护作用（AP）在链脲佐菌素诱导的糖尿病大鼠中。将大鼠分为对照组，糖尿病，糖尿病+格列美脲，糖尿病+ AP（150或300mg / Kg）组。单独使用AP（300 mg / Kg）可以降低空腹血清葡萄糖水平，但可以增加胰岛素水平和HOMA-β。在两种剂量下，AP均显着降低了糖尿病大鼠的肝中CHOL和LDL-C水平，并降低了TG，CHOL和LDL-C血清水平，而没有改变HDL-C的水平。而且，它们改善了肝脏结构，降低了ALT和AST的血清水平。同时，他们抑制了肝脏的MDA水平，并增加了肝脏的SOD，GSH，CAT和GPx水平。除脂质外，提取物的剂量越高，提取物对所有其他参数的影响就越深。总之，AP提取物具有降血糖，胰岛素释放，