ABSTRACT

Th17 cells remain one of the most important subsets of T cells in numerous autoimmune and chronic inflammatory diseases. Posttranscriptional regulation (PTR), especially mRNA stability, has recently emerged as an important mechanism that controls the fate of Th17 cells. This review summarizes the current knowledge on RNA-binding proteins (RBPs), microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) that induce mRNA stability changes and their roles in mediating the differentiation, proliferation, function, and migration of Th17 cells. In addition, we summarize the role of RNA modifications and nonsense-mediated mRNA decay (NMD) in Th17 cells. Ongoing research will help to identify practical applications for the regulation of mRNA stability and provide potential targets to prevent and treat Th17-related autoimmune diseases.

摘要

Th17 细胞仍然是众多自身免疫和慢性炎症疾病中最重要的 T 细胞亚群之一。转录后调控 (PTR)，尤其是 mRNA 稳定性，最近已成为控制 Th17 细胞命运的重要机制。本综述总结了目前关于诱导 mRNA 稳定性变化的 RNA 结合蛋白 (RBPs)、microRNAs (miRNAs) 和长链非编码 RNAs (lncRNAs) 的知识及其在介导 Th17 细胞分化、增殖、功能和迁移中的作用。 . 此外，我们总结了 RNA 修饰和无义介导的 mRNA 衰减 (NMD) 在 Th17 细胞中的作用。正在进行的研究将有助于确定 mRNA 稳定性调节的实际应用，并为预防和治疗 Th17 相关的自身免疫性疾病提供潜在的靶点。