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The Role of Diet-Derived Short Chain Fatty Acids in Regulating Cardiac Pressure Overload
American Journal of Physiology-Heart and Circulatory Physiology ( IF 4.1 ) Pub Date : 2020-12-11 , DOI: 10.1152/ajpheart.00573.2020
Nikolai Pakhomov 1 , John A Baugh 2
Affiliation  

Heart failure (HF) is one of the leading causes of mortality and morbidity in the modern world whose increasing prevalence is associated with "Western" diet and sedentary lifestyles. Of particular concern is the increasing burden of HF with preserved ejection fraction (HFpEF) that involves complex pathophysiology and is difficult to treat. Pressure overload caused by hypertension (HTN) is the predominant driver of cardiac injury, left ventricular hypertrophy, and fibrosis that progresses to diastolic dysfunction and ultimately HFpEF. While pharmacological control of blood pressure may affect the degree of pressure overload, such therapies are largely ineffective in established HFpEF and there is a need to modulate the festering inflammatory and fibrotic response to injury in order to halt and perhaps reverse pathology. An emerging literature indicates potentially important links between the gut microbiota, dietary soluble fiber, and microbiota-derived metabolites that modulate blood pressure and the immune response. In particular, high-fiber diets demonstrate protective properties in systemic hypertension and left-sided cardiac pathology and this action is closely associated with short chain fatty acid (SCFA) producing bacteria. Mechanisms underlying the beneficial action of SCFAs in immunity and the systemic circulation could potentially be applied to the treatment of hypertension and the cardiac damage it causes. In this review we discuss the potential beneficial effects of SCFAs with an emphasis on mechanisms that are involved in cardiac responses to pressure overload.

中文翻译:

饮食来源的短链脂肪酸在调节心脏压力超负荷中的作用

心力衰竭(HF)是现代世界中死亡率和发病率的主要原因之一,其患病率与“西方”饮食和久坐的生活方式有关。特别令人关注的是,射血分数(HFpEF)保留的HF负担增加,这涉及复杂的病理生理学且难以治疗。高血压(HTN)引起的压力超负荷是导致心脏损伤,左心室肥大和纤维化的主要驱动因素,后者逐渐发展为舒张功能障碍,最终导致HFpEF。虽然血压的药理控制可能会影响压力超负荷的程度,但此类疗法在建立的HFpEF中基本上无效,因此有必要调节对损伤的恶化性炎症和纤维化反应,以阻止甚至逆转病理。新兴的文献表明肠道微生物群,膳食可溶性纤维和微生物群衍生的代谢物之间的潜在重要联系,这些代谢物可调节血压和免疫反应。特别是,高纤维饮食在全身性高血压和左侧心脏病变中表现出保护作用,并且这种作用与产生短链脂肪酸(SCFA)的细菌密切相关。SCFAs在免疫和全身循环中的有益作用的潜在机制可能会应用于治疗高血压及其引起的心脏损害。在这篇综述中,我们讨论了SCFAs的潜在有益作用,重点是涉及心脏对压力超负荷反应的机制。以及微生物来源的代谢产物可调节血压和免疫反应。特别是,高纤维饮食在全身性高血压和左侧心脏病变中表现出保护作用,并且这种作用与产生短链脂肪酸(SCFA)的细菌密切相关。SCFAs在免疫和全身循环中的有益作用的潜在机制可能会应用于治疗高血压及其引起的心脏损害。在这篇综述中,我们讨论了SCFAs的潜在有益作用,重点是涉及心脏对压力超负荷反应的机制。以及微生物来源的代谢产物可调节血压和免疫反应。特别是,高纤维饮食在全身性高血压和左侧心脏病变中表现出保护作用,并且这种作用与产生短链脂肪酸(SCFA)的细菌密切相关。SCFAs在免疫和全身循环中的有益作用的潜在机制可能会应用于治疗高血压及其引起的心脏损害。在这篇综述中,我们讨论了SCFAs的潜在有益作用,重点是涉及心脏对压力超负荷反应的机制。高纤维饮食在全身性高血压和左侧心脏病变中显示出保护作用,并且这种作用与产生短链脂肪酸(SCFA)的细菌密切相关。SCFAs在免疫和全身循环中的有益作用的潜在机制可能会应用于治疗高血压及其引起的心脏损害。在这篇综述中,我们讨论了SCFAs的潜在有益作用,重点是涉及心脏对压力超负荷反应的机制。高纤维饮食在全身性高血压和左侧心脏病变中显示出保护作用,并且这种作用与产生短链脂肪酸(SCFA)的细菌密切相关。SCFAs在免疫和全身循环中的有益作用的潜在机制可能会应用于治疗高血压及其引起的心脏损害。在这篇综述中,我们讨论了SCFAs的潜在有益作用,重点是涉及心脏对压力超负荷反应的机制。
更新日期:2020-12-12
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