In this communication flow Friedel–Crafts alkylation was studied using hydroxy‐substituted sulfonic acid‐functionalized silica as a catalyst and 1‐adamantanol as a model substrate. The reaction of 1‐adamantanol (1a) with toluene (2a) proceeded well with 5 min of residence time at 120°C to give good yield of 1‐tolyladamantane (3a) as a 1:9 mixture of meta and para isomers. When the flow synthesis was carried out over 2.5 hr of running time, the collected five fractions contain the product 3a in 97–92% yields, suggesting the durability of the catalyst.

中文翻译：

---

使用HO-SAS作为固定化酸催化剂，使用芳烃进行Friedel-Crafts与芳烃的烷基化反应

在此交流流中，使用羟基取代的磺酸官能化的二氧化硅作为催化剂，以1-金刚烷醇为模型底物，研究了Friedel-Crafts烷基化反应。1-金刚烷醇（1a）与甲苯（2a）的反应在120°C的停留时间为5分钟的情况下进行得很好，从而以1-9的间位和对位异构体混合物形式获得了1-甲苯金刚烷（3a）的良好产率。当在2.5小时的运行时间内进行流动合成时，收集到的5个馏分中的产物3a的产率为97-92％，这表明催化剂具有耐久性。